Lipid and non-lipid factors affecting macrophage dysfunction and inflammation in atherosclerosis

MS Gibson, N Domingues, OV Vieira - Frontiers in physiology, 2018 - frontiersin.org
Atherosclerosis is a chronic inflammatory disease and a leading cause of human mortality.
The lesional microenvironment contains a complex accumulation of variably oxidized lipids …

Macrophages in atherosclerosis: a dynamic balance

KJ Moore, FJ Sheedy, EA Fisher - Nature Reviews Immunology, 2013 - nature.com
Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Phenotypic modulation of macrophages in response to plaque lipids

S Adamson, N Leitinger - Current opinion in lipidology, 2011 - journals.lww.com
Phenotypic modulation of macrophages in response to plaque l... : Current Opinion in
Lipidology Phenotypic modulation of macrophages in response to plaque lipids : Current …

Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications

L Dib, LA Koneva, A Edsfeldt, YX Zurke, J Sun… - Nature cardiovascular …, 2023 - nature.com
The immune system is integral to cardiovascular health and disease. Targeting inflammation
ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of …

Phenotypic polarization of macrophages in atherosclerosis

N Leitinger, IG Schulman - Arteriosclerosis, thrombosis, and …, 2013 - Am Heart Assoc
Macrophages orchestrate the inflammatory response in inflamed tissues, and recent work
indicates that these cells can alter their phenotypes and functions accordingly in response to …

Recognition of oxidized lipids by macrophages and its role in atherosclerosis development

NV Mushenkova, EE Bezsonov, VA Orekhova… - Biomedicines, 2021 - mdpi.com
Atherosclerosis is a multifactorial chronic disease that has a prominent inflammatory
component. Currently, atherosclerosis is regarded as an active autoimmune process that …

Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis

JA van Diepen, JFP Berbée, LM Havekes… - Atherosclerosis, 2013 - Elsevier
Dyslipidemia and inflammation are well known causal risk factors the development of
atherosclerosis. The interplay between lipid metabolism and inflammation at multiple levels …

Oxidized lipids: the two faces of vascular inflammation

KG Birukov - Current atherosclerosis reports, 2006 - Springer
Elevated plasma levels of low-density lipoprotein and generation of oxidized low-density
lipoprotein have been directly associated with the pathogenesis of atherosclerosis, and lipid …

The role of oxidized low‐density lipoproteins in atherosclerosis: the myths and the facts

G Maiolino, G Rossitto, P Caielli… - Mediators of …, 2013 - Wiley Online Library
The oxidative modification hypothesis of atherosclerosis, which assigns to oxidized low‐
density lipoproteins (LDLs) a crucial role in atherosclerosis initiation and progression, is still …

The iterative lipid impact on inflammation in atherosclerosis

JM Kraaijenhof, GK Hovingh, ESG Stroes… - Current opinion in …, 2021 - journals.lww.com
The iterative lipid impact on inflammation in atherosclerosi... : Current Opinion in Lipidology The
iterative lipid impact on inflammation in atherosclerosis : Current Opinion in Lipidology Log in or …