Intragenic recombination rapidly creates protein sequence diversity compared with random
mutation, but little is known about the relative effects of recombination and mutation on …

Reduced rates of genetic recombination are often associated with reduced genetic
variability and levels of adaptation. Several different evolutionary processes, collectively …

Genetic recombination can be broadly divided into two categories: homoloн gous
recombination and site-specific recombination. These pathways are distinguished by their …

Recombination, the process by which DNA strands are broken and repaired, producing new
combinations of alleles, occurs in nearly all multicellular organisms and has important …

In the two preceding sections, we discussed the mechanisms that allow the DNA sequences
in cells to be maintained from generation to generation with very little change. However, it is …

There is remarkable variation in the rate at which genetic incompatibilities in molecular
interactions accumulate. In some cases, minor changes—even single-nucleotide …

In this paper, we examine the conditions that allow increased recombination to evolve in the
presence of recurrent deleterious mutation. We focus on a three-locus model first studied by …

The prevalence of recombination in eukaryotes poses one of the most puzzling questions in
biology. The most compelling general explanation is that recombination facilitates selection …

Under the classical view, selection depends more or less directly on mutation: standing
genetic variance is maintained by a balance between selection and mutation, and …

One of the most widely cited hypotheses to explain the evolutionary maintenance of genetic
recombination states that the reshuffling of genotypes at meiosis increases the efficiency of …