Paxlovid (nirmatrelvir/ritonavir) effectiveness against hospitalization and death in N3C: A target trial emulation study

K Hansen, SR Makkar, D Sahner, J Fessel, N Hotaling… - medRxiv, 2023 - medrxiv.org
Importance COVID-19 has placed a monumental burden on the health care system globally.
Although no longer a public health emergency, there is still a pressing need for effective …

[HTML][HTML] Effect of Nirmatrelvir/Ritonavir (Paxlovid) on Hospitalization among Adults with COVID-19: an EHR-based Target Trial Emulation from N3C

A Bhatia, AJ Preiss, X Xiao, MD Brannock… - medRxiv, 2023 - ncbi.nlm.nih.gov
This study leverages electronic health record data in the National COVID Cohort
Collaborative's (N3C) repository to investigate disparities in Paxlovid treatment and to …

[PDF][PDF] Effectiveness of nirmatrelvir/ritonavir (Paxlovid®) in preventing hospitalisation and death among COVID-19 patients: a prospective cohort study

CL Sim, LX Jie, CC Tao, RS Kamaludin, LH Lunn… - MJM, 2023 - researchgate.net
Introduction: Previous trials and real-world studies have shown that nirmatrelvir/ritonavir
(Paxlovid®) reduces hospitalisation and deaths in symptomatic, high-risk, nonsevere COVID …

Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study

J Liu, X Pan, S Zhang, M Li, K Ma, C Fan… - The Lancet Regional …, 2023 - thelancet.com
Summary Background Nirmatrelvir plus ritonavir (Paxlovid) reduced the risk of
hospitalization or death by 89% in high-risk, ambulatory adults with COVID-19. We aimed at …

Describing COVID-19 Patients During The First Two Months of Paxlovid (Nirmatrelvir/Ritonavir) Initiation in a Large HMO in Israel

L Tene, G Chodick, N Fallach, W Ansari… - medRxiv, 2022 - medrxiv.org
Abstract Title Describing COVID-19 Patients During The First Two Months of Paxlovid
(Nirmatrelvir/Ritonavir) Initiation in a Large HMO in Israel Objective The objective of this …

Effectiveness of nirmatrelvir-ritonavir against hospital admission or death: a cohort study in a large US healthcare system

JA Lewnard, JM McLaughlin, D Malden, V Hong… - medRxiv, 2022 - medrxiv.org
ABSTRACT Background In the United States, oral nirmatrelvir-ritonavir (Paxlovid™) is
authorized for use among patients aged≥ 12 years with mild-to-moderate SARS-CoV-2 …

Real-world effectiveness of nirmatrelvir/ritonavir use for COVID-19: A population-based cohort study in Ontario, Canada

KL Schwartz, J Wang, M Tadrous, BJ Langford… - medRxiv, 2022 - medrxiv.org
Background Our objective was to evaluate the real world effectiveness of
nirmatrelvir/ritonavir to prevent severe COVID-19 while Omicron and its subvariants …

Comparative effectiveness of Paxlovid versus sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised patients: observational …

B Zheng, J Tazare, L Nab, A Mehrkar, B MacKenna… - medRxiv, 2023 - medrxiv.org
Objective To compare the effectiveness of Paxlovid vs. sotrovimab and molnupiravir in
preventing severe COVID-19 outcomes in non-hospitalised high-risk COVID-19 adult …

[HTML][HTML] Nirmatrelvir plus ritonavir for early COVID-19 and hospitalization in a large US health system

S Dryden-Peterson, A Kim, AY Kim, EC Caniglia… - medRxiv, 2022 - ncbi.nlm.nih.gov
Background: In the EPIC-HR trial, nirmatrelvir plus ritonavir led to an 88% reduction in
hospitalization or death among unvaccinated outpatients with early COVID-19. Clinical …

[PDF][PDF] COVID-19 antivirals utilization: geographic and demographic patterns of treatment in 2022

SJ Murphy, LW Samson, BD Sommers - Office of the Assistant …, 2022 - aspe.hhs.gov
BACKGROUND New COVID-19 oral antiviral treatments–Paxlovid (ritonavir-boosted
nirmatrelvir) 1 and Lagevrio (molnupiravir) 2–were first made available at the end of 2021 …