SS Dominy, C Lynch, F Ermini, M Benedyk… - Science …, 2019 - science.org
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called …
S Liu, CA Butler, S Ayton, EC Reynolds… - Critical Reviews in …, 2024 - Taylor & Francis
The cause of Alzheimer's disease (AD), and the pathophysiological mechanisms involved, remain major unanswered questions in medical science. Oral bacteria, especially those …
M Sadrameli, P Bathini, L Alberi - Current opinion in neurology, 2020 - journals.lww.com
The pathogens of periodontal disease and the subsequent chronic inflammatory responses have significant implications on the development of Alzheimer's disease. The exact …
SK Singhrao, A Harding, S Poole… - Mediators of …, 2015 - Wiley Online Library
Periodontal disease (PD) and Alzheimer's disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex …
Porphyromonas gingivalis is a Gram-negative, rod-shaped, obligate anaerobe that obtains its metabolic energy from protein breakdown products, heme, and vitamin K for its growth. It …
S Kanagasingam, SS Chukkapalli… - Journal of …, 2020 - content.iospress.com
Porphyromonas gingivalis (P. gingivalis) is one of the several important bacterial pathogens associated with the sporadic Alzheimer's disease (AD). Different serotypes are either …
MI Ryder, P Xenoudi - Periodontology 2000, 2021 - Wiley Online Library
Loss of cognitive function in the aging population, particular those with Alzheimer disease, presents unique challenges to health practitioners. For the dental practitioner these include …
SK Singhrao, I Olsen - Journal of oral microbiology, 2019 - Taylor & Francis
Chronic periodontitis of 10 years' duration is reported to become a twofold risk factor for the development of Alzheimer's disease (AD). Periodontitis is modifiable, and this fits with the …
G Jungbauer, A Stähli, X Zhu… - Periodontology …, 2022 - Wiley Online Library
In the initiation or exacerbation of Alzheimer disease, the dissemination of oral microorganisms into the brain tissue or the low‐level systemic inflammation have been …