Background: Paracoccidioidomycosis (PCM) is a chronic disease that causes sequelae and
requires prolonged treatment; therefore, new therapeutic approaches are necessary. In view …

For almost four decades, the nematode Caenorhabditis elegans has been of great value in
many fields of biological research. It is now used extensively in studies of microbial …

The spread of antibiotic resistance amongst bacterial pathogens has led to an urgent need
for new antimicrobial compounds with novel modes of action that minimize the potential for …

For the soil nematode Caenorhabditis elegans, microbes are both food source and potential
pathogens. Intrinsic antibiotic agents such as antimicrobial peptides (AMP) are important to …

Nematodes and arthropods likely form the taxon Ecdysozoa. Information on antimicrobial
effectors from the model nematode Caenorhabditis elegans may thus shed light on the …

The rise of multidrug-resistant Acinetobacter baumannii and a concomitant decrease in
antibiotic treatment options warrants a search for new classes of antibacterial agents. We …

Until very recently it was not known whether the invertebrate Caenorhabditis elegans was
capable of mounting a specific immune response to protect itself from pathogens. It has only …

In recent years, researchers investigating innate immunity have begun to use C. elegans as
a new model system. The worm has been found to mount protective responses to a variety of …

Organisms co-habiting with bacteria have developed efficient bactericidal agents to control
their microbe-rich environment. The Ascaris nematode lives in its final development stages …

The nematode Caenorhabditis elegans offers currently untapped potential for carrying out
high-throughput, live-animal screens of low molecular weight compound libraries to identify …