Single cell analyses encompass multiple approaches that, we suggest, can be summarized
by two unifying goals: to explain the cellular composition of tissues; and to characterize the …

In recent years, genome-wide profiling approaches have begun to uncover the molecular
programs that drive developmental processes. In particular, technical advances that enable …

Single-cell sequencing technologies have rapidly progressed in recent years, and been
applied to characterize stem cells in a number of organs. Somatic (postnatal) stem cells are …

High‐throughput‐omics techniques have revolutionised biology, allowing for thorough and
unbiased characterisation of the molecular states of biological systems. However, cellular …

During mammalian embryonic development, a single fertilized egg cell will proliferate and
differentiate into all the cell lineages and cell types that eventually form the adult organism …

A major goal of developmental biology is to understand the progression of embryonic cell
lineages from pluripotency to adulthood. During embryogenesis, cells proliferate and spread …

Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular
information at the individual cell level. Development of single-cell technologies and …

Cellular heterogeneity within a cell population is a common phenomenon in multicellular
organisms, tissues, cultured cells, and even FACS-sorted subpopulations. Important …

INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …

Major developmental processes such as gastrulation and early embryogenesis rely on a
complex network of cell–cell interactions, chromatin remodeling, and transcriptional …