Background There is no criterion reference for assessing healthy ageing and this creates
difficulties when conducting and comparing research on ageing across studies. A cardinal …

Aging is a major risk factor for most chronic diseases and functional impairments. Within a
homogeneous age sample there is a considerable variation in the extent of disease and …

Aging has pronounced effects on blood laboratory biomarkers used in the clinic. Prior
studies have largely investigated one biomarker or population at a time, limiting a …

Healthy ageing and longevity in humans result from a number of factors, including genetic
background, favorable environmental and social factors and chance. In this article we aimed …

A chronic disease in older adults usually runs a course that is less predictable than in
younger individuals. Unexplained variations in disease incidence, prognosis, therapeutic …

Multi-omics approach nowadays increasingly applied to molecular research in many fields
of life sciences. Biogerontology is not an exception; multi-omics gives possibility to evaluate …

Greater numbers of individuals are living to older ages. A major concern at both individual
and population levels is how to live these years at a high functional level. If we had …

Proteomic approaches have unique advantages in the identification of biological pathways
that influence physical frailty, a multifactorial geriatric syndrome predictive of adverse health …

Frailty is increasingly relevant for clinicians to improve care for vulnerable older adults.
Prominent frailty measures include the frailty phenotype and the frailty index. The frailty …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …