Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Improvements in public health and health care have resulted in significant increases in
lifespan globally, but also in a significant increase in chronic disease prevalence. This has …

Ageing is one of the most complex processes in nature; how could we prevent the
associated biological changes and chronic diseases that string along with this process, is a …

Inflammaging is a recent theory of aging originally proposed in 2000 where data and
conceptualizations regarding the aging of the immune system (immunosenescence) and the …

Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

The gut microbiome is undoubtedly a key modulator of human health, which can promote or
impair homeostasis throughout life. This is even more relevant in old age, when there is a …

Nowadays, people are living much longer than they used to do, however they are not free
from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and …

Successful aging is not a new concept, although its definition remains controversial,
because of its multi-dimensional nature. To the biomedical scientist, successful aging is …

Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism
itself deteriorate in a progressive and irreversible manner that, in the majority of cases …