Human aging and longevity are complex and multi-factorial traits that result from a
combination of environmental, genetic, epigenetic and stochastic factors, each contributing …

The molecular characteristics of aging that lead to increased disease susceptibility remain
poorly understood. Here we present a transcriptomic profile of the human brain associated …

Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …

Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

The early diagnosis of diseases frequently represents an important unmet clinical need
supporting in-time treatment of pathologies. This also applies to neurodegenerative …

The identification of plasma proteins that systematically change with age and, independent
of chronological age, predict accelerated decline of health is an expanding area of research …

Despite increasing research efforts, there is a lack of consensus on defining aging or health.
To understand the underlying processes, and to foster the development of targeted …

Ageing of the global population has become a public health concern with an important socio-
economic dimension. Ageing is characterized by an increase in the concentration of …

Global population aging poses a tremendous burden on the health care system worldwide.
Frailty is associated with decreased physical reserve and is considered an important …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …