A complete chart of the chromatin regulatory elements of immune cells in patients with
cancer and their dynamic behavior is necessary to understand the developmental fates and …

Diverse subtypes of renal cell carcinomas (RCCs) display a wide spectrum of
histomorphologies, proteogenomic alterations, immune cell infiltration patterns, and clinical …

An important challenge in the real-world management of patients with advanced clear-cell
renal cell carcinoma (aRCC) is determining who might benefit from immune checkpoint …

Background Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma
(ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here, we …

Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor
types due to high response rate to immunotherapies, despite low tumor mutational burden …

Intra-and interpatient heterogeneity of clear cell renal cell carcinoma (ccRCC) confounds the
search for therapies associated with durable tumor responses and predictive biomarkers …

Background Tumor-infiltrating immune cells have been linked to prognosis and response to
immunotherapy; however, the levels of distinct immune cell subsets and the signals that …

Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …

The tumor immune microenvironment plays a critical role in cancer progression and
response to immunotherapy in clear cell renal cell carcinoma (ccRCC), yet the composition …

Advanced clear cell renal cell carcinoma (ccRCC) frequently causes systemic inflammation.
Recent studies have shown that cancer cells reshape the immune landscape by secreting …