Overview Cancers are complex, adaptive systems comprised of cancer cells that are
influenced by supporting cells, immune cells, as well as soluble and insoluble proteins that …

Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical
level, but also at a tissue, organism, and population level. Multiple data streams, from …

Cancer systems biology aims to understand cancer as an integrated system of genes,
proteins, networks, and interactions rather than an entity of isolated molecular and cellular …

The unprecedented amount of data produced with high-throughput experimentation forces
biologists to employ mathematical representation and computation to glean meaningful …

Cancer research has focused on the identification of molecular differences between
cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules …

Abstract Systems biology takes an interdisciplinary approach to the systematic study of
complex interactions in biological systems. This approach seeks to decipher the emergent …

Systems biology uses systems of mathematical rules and formulas to study complex
biological phenomena. In cancer research there are three distinct threads in systems biology …

Translational medicine has been leveraging new technologies and tools for data analysis to
promote the development of new treatments. Integration of translational medicine with …

In recent years it has become clear that carcinogenesis is a complex process, both at the
molecular and cellular levels. Understanding the origins, growth and spread of cancer …

'The definitive property of individuality at the organismal level lies in the effective
suppression of the differential propagation of subparts as a necessary strategy for …