Mouse embryonic development is a canonical model system for studying mammalian cell
fate acquisition. Recently, single-cell atlases comprehensively charted embryonic …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …

Spatiotemporal orchestration of gene expression is required for proper embryonic
development. The use of single-cell technologies has begun to provide improved resolution …

Understanding of the molecular drivers of lineage diversification and tissue patterning
during primary germ layer development requires in-depth knowledge of the dynamic …

Following gastrulation, the three primary germ layers develop into the major organs in a
process known as organogenesis. Single-cell RNA sequencing has enabled the profiling of …

Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …

Traditionally, the mouse has been the favoured vertebrate model for biomedical research,
due to its experimental and genetic tractability. However, non-rodent embryological studies …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …

INTRODUCTION Metazoan development represents a big jump in complexity compared
with unicellular life in two aspects: cell-type differentiation and cell spatial organization. In …