Possible Susceptibility Genes for Intervention against Chemotherapy‐Induced Cardiotoxicity

X Yang, G Li, T Yang, M Guan, N An… - Oxidative Medicine …, 2020 - Wiley Online Library
Recent therapeutic advances have significantly improved the short‐and long‐term survival
rates in patients with heart disease and cancer. Survival in cancer patients may, however, be …

Anticancer drug-induced cardiotoxicity: insights and pharmacogenetics

A Adhikari, SMB Asdaq, MA Al Hawaj, M Chakraborty… - Pharmaceuticals, 2021 - mdpi.com
The advancement in therapy has provided a dramatic improvement in the rate of recovery
among cancer patients. However, this improved survival is also associated with enhanced …

Genetics of cancer therapy-associated cardiotoxicity

Y Kim, JG Seidman, CE Seidman - Journal of molecular and cellular …, 2022 - Elsevier
As the number of cancer survivors has increased significantly over the last decades due to
aging of population and development of effective cancer therapies, side effects from cancer …

Cardiotoxicity of anticancer drugs: Molecular mechanisms and strategies for cardioprotection

MB Morelli, C Bongiovanni, S Da Pra… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Pharmacogenomics as a risk mitigation strategy for chemotherapeutic cardiotoxicity

BC Jensen, HL McLeod - Pharmacogenomics, 2013 - Taylor & Francis
Damage to the heart can result from both traditional chemotherapeutic agents, such as
doxorubicin, and newer 'targeted 'therapies, such as trastuzumab. This chemotherapeutic …

Pharmacogenetics of chemotherapy-induced cardiotoxicity

VY Chang, JJ Wang - Current oncology reports, 2018 - Springer
Abstract Purpose of Review The goal of this review is to summarize current understanding of
pharmacogenetics and pharmacogenomics in chemotherapy-induced cardiotoxicity. Recent …

The future role of pharmacogenomics in anticancer agent-induced cardiovascular toxicity

T Magdy, PW Burridge - Pharmacogenomics, 2018 - Taylor & Francis
Toxicity to the heart and vascular system is a major concern with nearly all anticancer
agents. Toxicity can range from drug-induced hypertension, atherosclerosis (peripheral …

Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing?

T Magdy, BT Burmeister, PW Burridge - Pharmacology & therapeutics, 2016 - Elsevier
The cardiotoxicity of certain chemotherapeutic agents is now well-established, and has led
to the development of the field of cardio-oncology, increased cardiac screening of cancer …

Preclinical models of cancer therapy–associated cardiovascular toxicity: a scientific statement from the American heart association

A Asnani, JJ Moslehi, BB Adhikari, AH Baik… - Circulation …, 2021 - Am Heart Assoc
Although cardiovascular toxicity from traditional chemotherapies has been well recognized
for decades, the recent explosion of effective novel targeted cancer therapies with …

Cardiotoxicity of anti-cancer drugs: cellular mechanisms and clinical implications

C Kwok, M Nolan - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Cardio-oncology is an emerging field that seeks to enhance quality of life and longevity of
cancer survivors. It is pertinent for clinicians to understand the cellular mechanisms of …