Genetic factors affect an individual's risk of developing obesity, but in most cases each
genetic variant has a small effect. Discovery of genes that regulate obesity may provide …

The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Obesity is a major health issue that has reached pandemic status with no clear solutions.
Much has been learned over the past 50 years about the regulation of body fat. Examples …

Life involves a continuous use of energy, but food intake, which supplies that energy, is
episodic. Feeding is switched on and off by a complex array of predominantly gut-derived …

Abstract Type 2 diabetes (T2D) and obesity represent major challenges for global public
health. They are at the forefront of international efforts to identify the genetic variation …

Obesity and type 2 diabetes mellitus (T2DM) often occur together and affect a growing
number of individuals in both the developed and developing worlds. Both are associated …

The incidence of metabolic disorders like type 2 diabetes (T2D) and obesity continue to
increase. Although it is evident that the increasing incidence of diabetes confers a global …

Alarming statistics show that the number of people affected by excessive weight has
surpassed 2 billion, representing approximately 30% of the world's population. The aim of …

Obesity is a classical complex trait, influenced by both genetic and lifestyle factors. The
number of obesity gene variants is currently unknown but, based on sound evolutionary …

Introduction.................................................................................................................................................
............................ 833 Rationale and Scope of Human Genetic Studies of …