[HTML][HTML] The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement

PJ Hotez, ME Bottazzi, DB Corry - Microbes and infection, 2020 - Elsevier
Increasing evidence points to host Th17 inflammatory responses as contributing to the
severe lung pathology and mortality of lower respiratory tract infections from coronaviruses …

A case for targeting Th17 cells and IL-17A in SARS-CoV-2 infections

M Orlov, PL Wander, ED Morrell… - The Journal of …, 2020 - journals.aai.org
Abstract SARS-CoV-2, the virus causing COVID-19, has infected millions and has caused
hundreds of thousands of fatalities. Risk factors for critical illness from SARS-CoV-2 infection …

COVID‐19 immunopathology with emphasis on Th17 response and cell‐based immunomodulation therapy: potential targets and challenges

A Pourgholaminejad… - Scandinavian Journal …, 2022 - Wiley Online Library
The role of the immune system against coronavirus disease 2019 (COVID‐19) is unknown in
many aspects, and the protective or pathologic mechanisms of the immune response are …

The role of Th17 response in COVID-19

D Martonik, A Parfieniuk-Kowerda, M Rogalska… - Cells, 2021 - mdpi.com
COVID-19 is an acute infectious disease of the respiratory system caused by infection with
the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission …

Clonal expansion and activation of tissue-resident memory-like TH17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Y Zhao, C Kilian, JE Turner, L Bosurgi, K Roedl… - Science …, 2021 - science.org
Hyperinflammation contributes to lung injury and subsequent acute respiratory distress
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19) …

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …

[PDF][PDF] Heightened innate immune responses in the respiratory tract of COVID-19 patients

Z Zhou, L Ren, L Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - Cell host & …, 2020 - cell.com
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome

I Karwaciak, A Sałkowska, K Karaś, J Dastych… - Vaccines, 2021 - mdpi.com
The pandemic of the new coronavirus SARS-CoV-2 (severe acute respiratory syndrome
coronavirus 2) has led to the deaths of more than 1.5 million people worldwide. SARS-CoV …

Immune responses during COVID-19 infection

C Melenotte, A Silvin, AG Goubet, I Lahmar… - …, 2020 - Taylor & Francis
Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV
(SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and …

Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy

T Shibabaw - Journal of inflammation research, 2020 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) is a globally communicable public health
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) …