[HTML][HTML] Longitudinal analyses reveal immunological misfiring in severe COVID-19

C Lucas, P Wong, J Klein, TBR Castro, J Silva… - Nature, 2020 - nature.com
Recent studies have provided insights into the pathogenesis of coronavirus disease 2019
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

[HTML][HTML] SARS-CoV-2-specific T cells in infection and vaccination

A Bertoletti, N Le Bert, M Qui, AT Tan - Cellular & molecular …, 2021 - nature.com
During viral infections, antibodies and T cells act together to prevent pathogen spread and
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …

[HTML][HTML] Immune response, inflammation, and the clinical spectrum of COVID-19

LF García - Frontiers in immunology, 2020 - frontiersin.org
The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly
extended to become a global sanitary and economic emergency. Its etiological agent is the …

[HTML][HTML] The first 12 months of COVID-19: a timeline of immunological insights

T Carvalho, F Krammer, A Iwasaki - Nature Reviews Immunology, 2021 - nature.com
Since the initial reports of a cluster of pneumonia cases of unidentified origin in Wuhan,
China, in December 2019, the novel coronavirus that causes this disease—severe acute …

Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome

D Weiskopf, KS Schmitz, MP Raadsen, A Grifoni… - Science …, 2020 - science.org
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …

Early insights into immune responses during COVID-19

AL St John, APS Rathore - The Journal of Immunology, 2020 - journals.aai.org
Abstract Coronavirus disease-2019 (COVID-19) is caused by the newly emerged virus
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was recently declared …

[HTML][HTML] Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

KE Remy, M Mazer, DA Striker, AH Ellebedy… - JCI insight, 2020 - ncbi.nlm.nih.gov
COVID-19–associated morbidity and mortality have been attributed to a pathologic host
response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine …

[HTML][HTML] The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

C Schultheiß, E Willscher, L Paschold, C Gottschick… - Cell Reports …, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …

[HTML][HTML] Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection

A Maroof, YM Yorgensen, Y Li, JT Evans - PLoS pathogens, 2014 - journals.plos.org
Influenza disease is a global health issue that causes significant morbidity and mortality
through seasonal epidemics. Currently, inactivated influenza virus vaccines given …