Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies

SM Kissler, JR Fauver, C Mack, SW Olesen, C Tai… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and
can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA …

Clinical performance of SARS-CoV-2 molecular tests

DA Green, J Zucker, LF Westblade… - Journal of clinical …, 2020 - Am Soc Microbiol
Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the clinical …

Longitudinal assessment of diagnostic test performance over the course of acute SARS-CoV-2 infection

RL Smith, LL Gibson, PP Martinez, R Ke… - The Journal of …, 2021 - academic.oup.com
Background Serial screening is critical for restricting spread of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) by facilitating timely identification of infected …

Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections

J Hellewell, TW Russell, R Beale, G Kelly, C Houlihan… - BMC medicine, 2021 - Springer
Background Routine asymptomatic testing using RT-PCR of people who interact with
vulnerable populations, such as medical staff in hospitals or care workers in care homes …

Can testing predict SARS-CoV-2 infectivity? The potential for certain methods to be surrogates for replication-competent virus

MJ Binnicker - Journal of clinical microbiology, 2021 - Am Soc Microbiol
Since the beginning of the COVID-19 pandemic, molecular methods (eg, real-time PCR)
have been the primary means of diagnosing the disease. It is now well established that …

Estimating infectiousness throughout SARS-CoV-2 infection course

TC Jones, G Biele, B Mühlemann, T Veith, J Schneider… - Science, 2021 - science.org
INTRODUCTION Although post facto studies have revealed the importance of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from presymptomatic …

Direct comparison of SARS-CoV-2 analytical limits of detection across seven molecular assays

B Fung, A Gopez, V Servellita, S Arevalo… - Journal of clinical …, 2020 - Am Soc Microbiol
Analytical sensitivity for SARS-CoV-2 detection is a key performance metric for the
evaluation of viral detection assays. We determined analytical limits of detection for seven …

Epidemiological correlates of polymerase chain reaction cycle threshold values in the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

PP Salvatore, P Dawson, A Wadhwa… - Clinical Infectious …, 2021 - academic.oup.com
Background Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has principally been performed through the use of real-time reverse-transcription …

Validation and verification of the Abbott RealTime SARS-CoV-2 assay analytical and clinical performance

E Degli-Angeli, J Dragavon, ML Huang, D Lucic… - Journal of Clinical …, 2020 - Elsevier
Background High-throughput assays for the SARS-CoV-2 virus are critical to increasing test
capacity and slowing the spread of COVID-19. Abbott Molecular developed and received …

Quantitative SARS-CoV-2 viral-load curves in paired saliva samples and nasal swabs inform appropriate respiratory sampling site and analytical test sensitivity …

ES Savela, A Viloria Winnett, AE Romano… - Journal of clinical …, 2022 - Am Soc Microbiol
Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and
presymptomatic transmission, curb the spread of variants, and maximize treatment efficacy …