[PDF][PDF] Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations

RE Peterson, K Kuchenbaecker, RK Walters, CY Chen… - Cell, 2019 - cell.com
Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …

Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores

AI Campos, S Namba, SC Lin, K Nam, J Sidorenko… - Nature Genetics, 2023 - nature.com
Genome-wide association studies (GWASs) have been mostly conducted in populations of
European ancestry, which currently limits the transferability of their findings to other …

[HTML][HTML] Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study

C Medina-Gomez, JF Felix, K Estrada… - European journal of …, 2015 - Springer
Genome-wide association studies (GWAS) have been successful in identifying loci
associated with a wide range of complex human traits and diseases. Up to now, the majority …

Consistency of genome-wide associations across major ancestral groups

EE Ntzani, G Liberopoulos, TA Manolio, JPA Ioannidis - Human genetics, 2012 - Springer
It is not well known whether genetic markers identified through genome-wide association
studies (GWAS) confer similar or different risks across people of different ancestry. We …

[HTML][HTML] GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies

T Beck, RK Hastings, S Gollapudi, RC Free… - European journal of …, 2014 - nature.com
To facilitate broad and convenient integrative visualization of and access to GWAS data, we
have created the GWAS Central resource (http://www. gwascentral. org). This database …

[HTML][HTML] A scientometric review of genome-wide association studies

MC Mills, C Rahal - Communications biology, 2019 - nature.com
This scientometric review of genome-wide association studies (GWAS) from 2005 to 2018
(3639 studies; 3508 traits) reveals extraordinary increases in sample sizes, rates of …

[HTML][HTML] Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations

YR Li, BJ Keating - Genome medicine, 2014 - Springer
Genome-wide association studies (GWASs) are the method most often used by geneticists
to interrogate the human genome, and they provide a cost-effective way to identify the …

[HTML][HTML] Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study

CS Carlson, TC Matise, KE North, CA Haiman… - PLoS …, 2013 - journals.plos.org
The vast majority of genome-wide association study (GWAS) findings reported to date are
from populations with European Ancestry (EA), and it is not yet clear how broadly the genetic …

Genome-wide association studies in diverse populations

NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …

Next generation disparities in human genomics: concerns and remedies

AC Need, DB Goldstein - Trends in Genetics, 2009 - cell.com
Studies of human genetics, particularly genome-wide association studies (GWAS), have
concentrated heavily on European populations, with individuals of African ancestry rarely …