Heterocyclic scaffolds are commonly found in numerous biologically active molecules,
therapeutic agents, and agrochemicals. To probe chemical space around heterocycles …

This review article features selected examples on the synthesis of functionalized pyrroles
that were reported between 2014 and 2019. Pyrrole is an important nitrogen-containing …

The skeletal editing of azaarenes through insertion, deletion, or swapping of single atoms
has recently gained considerable momentum in chemical synthesis. Here, we describe a …

Ring contraction of larger rings is one of the important tools in the repertoire of the methods
for the synthesis of pyrroles and has long been described in the literature. This methodology …

Benzocycloheptenes constitute a common structural motif embedded in many natural
products and biologically active compounds. Herein, we report their concise preparation …

Skeletal editing involves making specific point‐changes to the core of a molecule through
the selective insertion, deletion or exchange of atoms. It thus represents a potentially …

Given the ubiquity of heterocycles in biologically active molecules, transformations with the
capacity to modify such molecular skeletons with modularity remain highly desirable. Ring …

A method for the conversion of pyrimidines into pyrazoles by a formal carbon deletion has
been achieved guided by computational analysis. The pyrimidine heterocycle is the most …

Saturated N-heterocyclic pyrrolidines are common in natural products, medicinal
compounds and agrochemicals. However, reconstruction of their skeletal structures creating …

Reactions that lead to destruction of aromatic ring systems often require harsh conditions
and, thus, take place with poor selectivities. Selective partial dearomatization of fused …