Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19

L Milross, J Majo, N Cooper, PM Kaye… - The Lancet …, 2022 - thelancet.com
The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue
provides crucial insights into the pathophysiology of severe disease. From basic histology to …

[HTML][HTML] Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

L Carsana, A Sonzogni, A Nasr, RS Rossi… - The Lancet infectious …, 2020 - thelancet.com
Background COVID-19 is characterised by respiratory symptoms, which deteriorate into
respiratory failure in a substantial proportion of cases, requiring intensive care in up to a …

[HTML][HTML] Two distinct immunopathological profiles in autopsy lungs of COVID-19

R Nienhold, Y Ciani, VH Koelzer, A Tzankov… - Nature …, 2020 - nature.com
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide …

[HTML][HTML] Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists

F Calabrese, F Pezzuto, F Fortarezza, P Hofman, I Kern… - Virchows archiv, 2020 - Springer
Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has
quickly spread to a pandemic infectious disease. The causative agent has been recognized …

Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

A Budhraja, A Basu, A Gheware… - Disease Models & …, 2022 - journals.biologists.com
To elucidate the molecular mechanisms that manifest lung abnormalities during severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole …

[HTML][HTML] The pathology of severe COVID-19-related lung damage: Mechanistic and therapeutic implications

FKF Kommoss, C Schwab, L Tavernar… - Deutsches Ärzteblatt …, 2020 - ncbi.nlm.nih.gov
Background The histomorphological changes of lung damage in severe coronavirus
disease 2019 (COVID-19) have not yet been adequately characterized. In this article, we …

Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studies

JL Sauter, MK Baine, KJ Butnor, DJ Buonocore… - …, 2020 - Wiley Online Library
Introduction We describe post‐mortem pulmonary histopathologic findings of COVID‐19
pneumonia in patients with a spectrum of disease course, from rapid demise to prolonged …

Pathological post‐mortem findings in lungs infected with SARS‐CoV‐2

S Damiani, M Fiorentino, A De Palma… - The Journal of …, 2021 - Wiley Online Library
Italy was the first European nation to be massively infected by SARS‐CoV‐2. Up to the end
of May 2020, more than 33,000 deaths had been recorded in Italy, with a large prevalence …

[HTML][HTML] The pulmonary pathology of COVID-19

H Bösmüller, M Matter, F Fend, A Tzankov - Virchows Archiv, 2021 - Springer
The lung is the main affected organ in severe coronavirus disease 2019 (COVID-19) caused
by the novel coronavirus SARS-CoV-2, and lung damage is the leading cause of death in …

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science Translational …, 2021 - science.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …