The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the
transcription of cellular genes required for DNA replication and cell division. Recent …

The retinoblastoma protein, Rb, is encoded by a classic tumor suppressor gene that is
mutated in a large variety of tumors. Extensive studies have suggested that Rb functions as …

The retinoblastoma gene product is an abundant nuclear protein whose 'pocket
domain'mediates numerous protein–protein interactions. A substantial proportion of the RB …

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified
and plays a fundamental role in regulation of progression through the cell cycle. This review …

The retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly
conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

The retinoblastoma protein, pRb, controls transcription through recruitment of histone
deacetylase to particular E2F-responsive genes. We determined the acetylation level of …

The retinoblastoma (pRb) family of proteins are well known for their tumor suppressor
properties and for their ability to regulate transcription. The action of pRb family members …

Retinoblastoma, the most common primary intraocular cancer of childhood, is a malignancy
arising in the developing retina. Tumor formation usually begins with mutation in both alleles …