Immune responses involve coordination across cell types and tissues. However, studies in
cancer immunotherapy have focused heavily on local immune responses in the tumor …

Understanding of the factors governing immune responses in cancer remains incomplete,
limiting patient benefit. In this study, we used mass cytometry to define the systemic immune …

Purpose: Throughout their development, tumors are challenged by the immune system, and
they acquire features to evade its surveillance. A systematic view of these traits, which shed …

With the recent advent of immunotherapy, there is a critical need to understand immune cell
interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts …

Understanding the spontaneous immune response of cancer patients is critical for the
design of efficient anticancer immunotherapies. The power of integrative tumor immunology …

Simple Summary Cell-to-cell communication between the immune system and tumors is of
the utmost importance; it influences the development of tumors, their growth, and how they …

Immune profiling has been widely used to probe mechanisms of immune escape in cancer
and identify novel targets for therapy. Two emerging uses of immune signatures are to …

Immunotherapy has revolutionized cancer therapy, largely attributed to the success of
immune-checkpoint blockade. However, there are subsets of patients across multiple …

The extent to which immune cell phenotypes in the peripheral blood reflect within-tumor
immune activity prior to and early in cancer therapy is unclear. To address this question, we …

Murine syngeneic tumor models are critical to novel immuno-based therapy development,
but the molecular and immunologic features of these models are still not clearly defined. The …