Evolution and epidemic spread of SARS-CoV-2 in Brazil

DS Candido, IM Claro, JG De Jesus, WM Souza… - Science, 2020 - science.org
Brazil currently has one of the fastest-growing severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data …

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

JJA van Kampen, DAMC van de Vijver… - Nature …, 2021 - nature.com
Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …

Severity of severe acute respiratory system coronavirus 2 (SARS-CoV-2) alpha variant (B. 1.1. 7) in England

DJ Grint, K Wing, C Houlihan, HP Gibbs… - Clinical Infectious …, 2022 - academic.oup.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alpha
variant (B. 1.1. 7) is associated with higher transmissibility than wild-type virus, becoming the …

Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020

A Singanayagam, M Patel, A Charlett… - …, 2020 - eurosurveillance.org
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract
peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate …

Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event

H Streeck, B Schulte, BM Kümmerer, E Richter, T Höller… - medrxiv, 2020 - medrxiv.org
The world faces an unprecedented SARS-CoV2 pandemic where many critical factors still
remain unknown. The case fatality rates (CFR) reported in the context of the SARS-CoV-2 …

Quantitative SARS-CoV-2 viral-load curves in paired saliva samples and nasal swabs inform appropriate respiratory sampling site and analytical test sensitivity …

ES Savela, A Viloria Winnett, AE Romano… - Journal of clinical …, 2022 - Am Soc Microbiol
Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and
presymptomatic transmission, curb the spread of variants, and maximize treatment efficacy …

Can testing predict SARS-CoV-2 infectivity? The potential for certain methods to be surrogates for replication-competent virus

MJ Binnicker - Journal of clinical microbiology, 2021 - Am Soc Microbiol
Since the beginning of the COVID-19 pandemic, molecular methods (eg, real-time PCR)
have been the primary means of diagnosing the disease. It is now well established that …

The engines of SARS-CoV-2 spread

EC Lee, NI Wada, MK Grabowski, ES Gurley, J Lessler - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly across
the globe, causing epidemics that range from quickly controlled local outbreaks (such as …

Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Nature medicine, 2020 - nature.com
Data on the detailed clinical progression of COVID-19 in conjunction with epidemiological
and virological characteristics are limited. In this case series, we describe the first 12 US …

Evaluation of two RT-PCR screening assays for identifying SARS-CoV-2 variants

M Migueres, S Lhomme, P Trémeaux… - Journal of Clinical …, 2021 - Elsevier
Background The recent emergence of new SARS CoV-2 variants (variants of concern, VOC)
that spread rapidly and may lead to immune escape has emphasized the urgent need to …