IL-33: a jack of all trades in the orchestration of respiratory antibacterial immunity

JD Boehme, D Bruder - Cellular & Molecular Immunology, 2017 - nature.com
Influenza A virus (IAV) is the causative agent of mostly mild to moderate seasonal respiratory
infections and several pandemic outbreaks, the most recent of which was reported in 2009 …

[HTML][HTML] A novel function of IL-33: suppression of innate antiviral immunity

A Matsuda - Journal of Thoracic Disease, 2016 - ncbi.nlm.nih.gov
© Journal of Thoracic Disease. All rights reserved. J Thorac Dis 2016; 8 (10): E1364-E1366
jtd. amegroups. com including group 2 innate lymphoid cells (ILC2), Th2 cells, eosinophils …

[HTML][HTML] Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection

KM Robinson, K Ramanan, ME Clay, KJ McHugh… - Mucosal …, 2018 - Elsevier
Influenza A is a highly contagious respiratory virus that causes seasonal epidemics and
occasional worldwide pandemics. The primary cause of influenza-related mortality is …

Interleukin-33 and the function of innate lymphoid cells

AS Mirchandani, RJ Salmond, FY Liew - Trends in immunology, 2012 - cell.com
Interleukin (IL)-33 is a member of the IL-1 cytokine family that has been shown to play an
important role in the induction and effector phases of type 2 immune responses. Both innate …

The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases

S Gu, R Wang, W Zhang, C Wen, C Chen… - Frontiers in …, 2024 - frontiersin.org
Epithelial-derived IL-33 (Interleukin-33), as a member of alarm signals, is a chemical
substance produced under harmful stimuli that can promote innate immunity and activate …

Linking acute infection to chronic lung disease. The role of IL-33–expressing epithelial progenitor cells

MJ Holtzman, DE Byers, JA Brett, AC Patel… - Annals of the …, 2014 - atsjournals.org
Respiratory infection is a common feature of the major human airway diseases, such as
asthma and chronic obstructive pulmonary disease, but the precise link between acute …

IL-33 in chronic respiratory disease: from preclinical to clinical studies

C Donovan, PM Hansbro - ACS pharmacology & translational …, 2019 - ACS Publications
IL-33 has been deorphanized as a member of the IL-1 family and has key roles as an
alarmin and cytokine with potent capacity to drive type 2 inflammation. This has led to a …

Uncovering the Complexities of Interleukin-33 Signalling in COPD

FA Easton, DJ Cousins - 2023 - figshare.le.ac.uk
Interleukin-33 (IL-33) is an alarmin cytokine released by airway epithelial cells in response
to damage or infection (1, 2). The IL-33 receptor, known as ST2, is found as a …

Crucial and diverse role of the interleukin-33/ST2 axis in infectious diseases

O Rostan, MI Arshad, C Piquet-Pellorce… - Infection and …, 2015 - Am Soc Microbiol
ABSTRACT Interleukin-33 (IL-33) has now emerged as a cytokine with diverse and
pleiotropic functions in various infectious and inflammatory diseases. IL-33 is expressed by …

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

I Röwekamp, L Maschirow, A Rabes… - Proceedings of the …, 2024 - National Acad Sciences
IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production
is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its …