Adverse drug reactions (ADRs) are noxious and unexpected effects during normal drug
therapy. They have caused significant clinical burden and been responsible for a large …

Introduction Efficient searching and coding in databases that use terminological resources
requires that they support efficient data retrieval. The Medical Dictionary for Regulatory …

Although MedDRA has obvious advantages over previous terminologies for coding adverse
drug reactions and discovering potential signals using data mining techniques, its …

Objective Adverse drug reaction (ADR) is one of the major causes of failure in drug
development. Severe ADRs that go undetected until the post-marketing phase of a drug …

Abstract Background Adverse Drug Reactions (ADRs) are of great public health concern.
FDA-approved drug labeling summarizes ADRs of a drug product mainly in three sections …

Adverse drug reactions (ADRs) are a major public health concern, causing over 100,000
fatalities in the United States every year with an annual cost of $136 billion. Early detection …

Delivering safe and effective therapeutic treatment to patients is one of the grand challenges
in modern medicine. However, drug safety research has been progressing slowly in recent …

Abstract Background The Adverse Event Reporting System (AERS) is an FDA database
providing rich information on voluntary reports of adverse drug events (ADEs). Normalizing …

The WHO-ART and MedDRA terminologies used for coding adverse drug reactions (ADR)
do not provide formal definitions of terms. In order to improve groupings, we propose to map …

An adverse drug reaction (ADR) often results from interaction of a drug or its metabolites
with specific protein targets important in normal cellular function. Knowledge about these …