The fetal inflammatory response syndrome

F Gotsch, R Romero, JP Kusanovic… - Clinical obstetrics and …, 2007 - journals.lww.com
The fetal inflammatory response syndrome (FIRS) is a condition characterized by systemic
inflammation and an elevation of fetal plasma interleukin-6. This syndrome has been …

Midtrimester amniotic fluid concentrations of interleukin-6 and interferon-gamma-inducible protein-10: evidence for heterogeneity of intra-amniotic inflammation and …

MT Gervasi, R Romero, G Bracalente… - Journal of perinatal …, 2012 - degruyter.com
Introduction: Intra-amniotic inflammation is traditionally defined as an elevation of amniotic
fluid interleukin (IL)-6. Previous case control studies have suggested an association …

Maternal serum interleukin-6 concentrations in patients with preterm premature rupture of membranes and evidence of infection

AP Murtha, PC Greig, CE Jimmerson… - American journal of …, 1996 - Elsevier
OBJECTIVE: Our purpose was to determine whether maternal serum interleukin-6
concentrations are elevated in patients with preterm premature rupture of membranes and …

Predictive value of serum interleukin‐6 and‐8 levels in preterm labor or rupture of the membranes

G Von Minckwitz, EVAM GRISCHKE… - Acta Obstetricia et …, 2000 - Wiley Online Library
Background. The aim of this prospective study was to examine if serum concentrations of
cytokines are of value in the identification of patients at risk for preterm delivery. Methods …

Interleukin-10 in amniotic fluid at midtrimester: immune activation and suppression in relation to fetal growth

KD Heyborne, JA McGregor, G Henry, SS Witkin… - American journal of …, 1994 - Elsevier
OBJECTIVE: Low birth weight remains the leading cause of perinatal morbidity and
mortality, but mechanisms mediating impaired fetal growth are poorly understood. To further …

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10

F Gotsch, R Romero, JP Kusanovic, O Erez… - The Journal of …, 2008 - Taylor & Francis
Objective. The anti-inflammatory limb of the immune response is crucial for dampening
inflammation. Spontaneous parturition at term and preterm labor (PTL) are mediated by …

Amniotic fluid interleukin-6 levels correlate with histologic chorioamnionitis and amniotic fluid cultures in patients in premature labor with intact membranes

PC Greig, JM Ernest, L Teot, M Erikson… - American journal of …, 1993 - Elsevier
Objective: Our purpose was (1) to determine the frequency of intraamniotic and
extraamniotic intrauterine infection in patients with premature labor and intact membranes …

Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome

P Pacora, T Chaiworapongsa, E Maymon… - The Journal of …, 2002 - Taylor & Francis
Objective: To determine whether there is a relationship between the presence of histological
signs of inflammation in the extraplacental membranes and umbilical cord and the …

Amniotic fluid interleukin-10 concentrations increase through pregnancy and are elevated in patients with preterm labor associated with intrauterine infection

PC Greig, WNP Herbert, BL Robinette… - American journal of …, 1995 - Elsevier
OBJECTIVE: To better understand the role of the antiinflammatory cytokine interleukin-10 in
preterm labor and infection, we evaluated the amniotic fluid interleukin-10 concentrations …

Amniotic fluid interleukin-6 and preterm delivery: a review

AY El-Bastawissi, MA Williams, DE Riley, J Hitti… - Obstetrics & …, 2000 - Elsevier
Objective: To evaluate the potential role of amniotic fluid (AF) interleukin (IL)-6 as a predictor
of preterm delivery and to consider possible explanations for the proportion of women with …