[HTML][HTML] Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein: from mechanistic studies to clinical trials for COVID …
An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
[HTML][HTML] An update review of emerging small-molecule therapeutic options for COVID-19
D Tian, Y Liu, C Liang, L Xin, X Xie, D Zhang… - Biomedicine & …, 2021 - Elsevier
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a
challenge to global health. At present, many candidate small-molecule therapeutics have …
challenge to global health. At present, many candidate small-molecule therapeutics have …
[HTML][HTML] An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2
F Yan, F Gao - Computational and structural biotechnology journal, 2021 - Elsevier
There is an urgent need to develop effective treatments for coronavirus disease 2019
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19
M Chien, TK Anderson, S Jockusch, C Tao… - Journal of proteome …, 2020 - ACS Publications
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …
Identification and characterization of novel RdRp and Nsp15 inhibitors for SARS-COV2 using computational approach
Abstract The World Health Organization has declared COVID-19 as a global health
emergency. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 …
emergency. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 …
Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities
The newly emerged coronavirus, called SARS-CoV-2, is the causing pathogen of pandemic
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
[HTML][HTML] Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysis
Researchers are focused on discovering compounds that can interfere with the COVID-19
life cycle. One of the important non-structural proteins is endoribonuclease since it is …
life cycle. One of the important non-structural proteins is endoribonuclease since it is …
A high-throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex toward developing therapeutics for COVID-19
SARS-CoV-2, the coronavirus that causes COVID-19, evades the human immune system by
capping its RNA. This process protects the viral RNA and is essential for its replication …
capping its RNA. This process protects the viral RNA and is essential for its replication …
[HTML][HTML] Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19
HT Kao, A Orry, MG Palfreyman, B Porton - Scientific Reports, 2022 - nature.com
Nsp1 is one of the first proteins expressed from the SARS-CoV-2 genome and is a major
virulence factor for COVID-19. A rapid multiplexed assay for detecting the action of Nsp1 …
virulence factor for COVID-19. A rapid multiplexed assay for detecting the action of Nsp1 …
Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for …
N Imprachim, Y Yosaatmadja… - Nucleic Acids …, 2023 - academic.oup.com
NSP14 is a dual function enzyme containing an N-terminal exonuclease domain (ExoN) and
C-terminal Guanine-N7-methyltransferase (N7-MTase) domain. Both activities are essential …
C-terminal Guanine-N7-methyltransferase (N7-MTase) domain. Both activities are essential …