A recently emerged betacoronavirus, SARS-CoV-2, has led to a global health crisis that calls
for the identification of effective therapeutics for COVID-19 disease. Coronavirus papain-like …

Antiviral therapeutics is one effective avenue to control and end this devastating COVID-19
pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), possesses an
important bifunctional nonstructural protein (nsp14) with a C-terminal N7-methyltransferase …

Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, the harm caused
by coronaviruses to the world cannot be underestimated. Recently, a novel coronavirus …

The emergence of SARS-CoV-2 causing the COVID-19 pandemic, has highlighted how a
combination of urgency, collaboration and building on existing research can enable rapid …

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is unprecedented in human history. As a major structural protein …

The emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-
19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic …

Although several pharmacological agents are under investigation to be repurposed as
therapeutic against COVID-19, not much success has been achieved yet. So, the search for …

Nucleotide analogs targeting viral RNA polymerase have been proved to be an effective
strategy for antiviral treatment and are promising antiviral drugs to combat the current severe …

Abstract SARS-CoV-2, a member of the coronavirus family, is responsible for the current
COVID-19 worldwide pandemic. We previously demonstrated that five nucleotide analogues …