The prostate is a walnut-sized gland that surrounds the urethra of males at the base of the
bladder comprising a muscular portion, which controls the release of urine, and a glandular …

The study of prostate cancer in vitro relies on established cell lines that lack important
physiological characteristics, such as proper polarization and expression of relevant …

Lack of adequate models significantly hinders advances in prostate cancer treatment, where
resistance to androgen-deprivation therapies and bone metastasis remain as major …

In contrast to cell cultures, particularly to cell lines, tissues or organs removed from the body
cannot be maintained for long in any culture conditions. Although it is apparent that in vivo …

Open microfluidic cell culture systems are powerful tools for interrogating biological
mechanisms. We have previously presented a microscale cell culture system, based on …

We present a simple bench-top method to fabricate enclosed circular channels for biological
experiments. Fabricating the channels takes less than 2 hours by using glass capillaries of …

Biophysical and biochemical properties of the microenvironment regulate cellular responses
such as growth, differentiation, morphogenesis and migration in normal and cancer cells …

Here, we report a testis-on-chip platform for the ex vivo culture of seminiferous tubules
isolated from human and non-human primate testis. Tissues are cultured in a dedicated …

The urinary system, comprising the kidneys, ureters, bladder, and urethra, has a unique
mechanical and fluid microenvironment, which is essential to the urinary system growth and …

Paracrine function is a major mechanism of cell-cell communication within tissue
microenvironment in normal development and disease. In vitro cell culture models …