People with schizophrenia are enriched for rare coding variants in genes associated with
neurodevelopmental disorders, particularly autism spectrum disorders and intellectual …

To evaluate evidence for de novo etiologies in schizophrenia, we sequenced at high
coverage the exomes of families recruited from two populations with distinct demographic …

Functional and structural brain imaging has identified neural and neurotransmitter systems
involved in schizophrenia and their link to cognitive and behavioural disturbances such as …

Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …

With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise …

Schizophrenia is a debilitating mental illness that affects 1% of the population. Despite
intensive study, its molecular etiology remains enigmatic. Like many common diseases …

How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

Identifying the molecular alterations that underlie the pathophysiology of critical clinical
features of schizophrenia is an essential step in the rational development of new therapeutic …

Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%,. We …

Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …