We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …

Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to
genetic alterations, but identifying the genes responsible has proved challenging …

Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …

Whole exome sequencing has proven to be a powerful tool for understanding the genetic
architecture of human disease. Here we apply it to more than 2,500 simplex families, each …

Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental
condition characterized by marked genetic heterogeneity,,. Thus, a fundamental question is …

Importance Schizophrenia is a complex genetic disorder demonstrating considerable
heritability. Genetic studies have implicated many different genes and pathways, but much of …

AKT-GSK3β signaling is a target of lithium and as such has been implicated in the
pathogenesis of mood disorders. Here, we provide evidence that this signaling pathway also …

Schizophrenia is a complex disorder that interferes with the function of several brain systems
required for cognition and normal social behaviour. Although the most notable clinical …

Summary 22q11. 2 deletion carriers show specific cognitive deficits, and∼ 30% of them
develop schizophrenia. One of the disrupted genes is ZDHHC8, which encodes for a …

Schizophrenia is a highly polygenic disorder with important contributions from both common
and rare risk alleles. We analyzed exome sequencing data for de novo variants (DNVs) in a …