New findings are rapidly revealing an increasingly detailed image of neural-and molecular-
level dysfunction in schizophrenia, distributed throughout interconnected cortico–striato …

Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology.
Recently, the first common genetic variant associated on a genome-wide level with …

Genes disrupted in schizophrenia may be revealed by de novo mutations in affected
persons from otherwise healthy families. Furthermore, during normal brain development …

Some individuals with autism spectrum disorder (ASD) carry functional mutations rarely
observed in the general population. We explored the genes disrupted by these variants from …

Defining the environmental context in which genes enhance disease susceptibility can
provide insight into the pathogenesis of complex disorders. We report that the intra-uterine …

In 2018, psychiatrist Oleguer Plana-Ripoll was wrestling with a puzzling fact about mental
disorders. He knew that many individuals have multiple conditions--anxiety and depression …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Importance Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the
specific genetic variants and pathways that increase susceptibility to SCZ is critical to …

Numerous studies have examined gene expression profiles in post-mortem human brain
samples from individuals with schizophrenia compared with healthy controls, to gain insight …