INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …

Schizophrenia is believed to involve altered activation of dopamine receptors, and support
for this hypothesis conies from the antipsychotic effect of antagonists of the dopamine D2 …

Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …

Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic
etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have …

There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

Neuronal activity induces the post-translational modification of synaptic molecules, promotes
localized protein synthesis within dendrites and activates gene transcription, thereby …

Schizophrenia (SZ) is a severe psychotic disorder that is highly heritable and common in the
general population. The genetic heterogeneity of SZ is substantial, with contributions from …

Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized
by social and communication deficits and repetitive behaviors. For the majority of affected …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …

A small number of rare, recurrent genomic copy number variants (CNVs) are known to
substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity …