Dicer structure and function: conserved and evolving features
D Zapletal, K Kubicek, P Svoboda, R Stefl - EMBO reports, 2023 - embopress.org
RNase III Dicer produces small RNAs guiding sequence‐specific regulations, with important
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …
A glimpse of “Dicer Biology” through the structural and functional perspective
S Paturi, MV Deshmukh - Frontiers in molecular biosciences, 2021 - frontiersin.org
The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …
Production of small RNAs by mammalian Dicer
E Svobodova, J Kubikova, P Svoboda - Pflügers Archiv-European Journal …, 2016 - Springer
MicroRNA (miRNA) and RNA interference (RNAi) pathways employ RNase III Dicer for the
biogenesis of small RNAs guiding post-transcriptional repression. Requirements for Dicer …
biogenesis of small RNAs guiding post-transcriptional repression. Requirements for Dicer …
Substrate-specific structural rearrangements of human Dicer
DW Taylor, E Ma, H Shigematsu… - Nature structural & …, 2013 - nature.com
Dicer has a central role in RNA-interference pathways by cleaving double-stranded RNAs
(dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double …
(dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double …
Mammalian Dicer finds a partner
JJ Rossi - EMBO reports, 2005 - embopress.org
RNA interference (RNAi) is a complex process that uses small RNAs of 21–23 nucleotides to
guide sequence-specific silencing of genetic information at both the transcriptional and …
guide sequence-specific silencing of genetic information at both the transcriptional and …
[HTML][HTML] Coordinated activities of human dicer domains in regulatory RNA processing
The conserved ribonuclease Dicer generates microRNAs and short‐interfering RNAs that
guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural …
guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural …
Role of Dicer in posttranscriptional RNA silencing
L Jaskiewicz, W Filipowicz - RNA interference, 2008 - Springer
Dicer, an RNase III type endonuclease, is the key enzyme involved in RNA interference
(RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small …
(RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small …
Determinants of selectivity in the dicing mechanism
Our research elucidates the cleavage processes of the RNase III enzyme, DICER, which
plays a crucial role in the production of small RNAs, such as microRNAs (miRNAs) and …
plays a crucial role in the production of small RNAs, such as microRNAs (miRNAs) and …
Revealing a new activity of the human Dicer DUF283 domain in vitro
A Kurzynska-Kokorniak, M Pokornowska… - Scientific Reports, 2016 - nature.com
The ribonuclease Dicer is a multidomain enzyme that plays a fundamental role in the
biogenesis of small regulatory RNAs (srRNAs), which control gene expression by targeting …
biogenesis of small regulatory RNAs (srRNAs), which control gene expression by targeting …
Structural determinants of RNA recognition and cleavage by Dicer
A hallmark of RNA interference is the production of short double-stranded RNA (dsRNA)
molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer …
molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer …