(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
JA Losman, RE Looper, P Koivunen, S Lee… - Science, 2013 - science.org
Mutations in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are
common in several human cancers, including leukemias, and result in overproduction of the …
common in several human cancers, including leukemias, and result in overproduction of the …
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing
the altered metabolism of cancer cells for cancer therapy. One potential drug target is …
the altered metabolism of cancer cells for cancer therapy. One potential drug target is …
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
F Wang, J Travins, B DeLaBarre, V Penard-Lacronique… - Science, 2013 - science.org
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate
dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter residues in the enzyme …
dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter residues in the enzyme …
R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis
The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have
lost their normal catalytic activity and gained a novel function to produce R-2 …
lost their normal catalytic activity and gained a novel function to produce R-2 …
IDH1 (R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently
found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML) …
found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML) …
Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
A Chaturvedi, MM Araujo Cruz… - Blood, The Journal …, 2013 - ashpublications.org
Mutations in the metabolic enzymes isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are
frequently found in glioma, acute myeloid leukemia (AML), melanoma, thyroid cancer, and …
frequently found in glioma, acute myeloid leukemia (AML), melanoma, thyroid cancer, and …
What a difference a hydroxyl makes: mutant IDH,(R)-2-hydroxyglutarate, and cancer
JA Losman, WG Kaelin - Genes & development, 2013 - genesdev.cshlp.org
Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in
gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel …
gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel …
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance
Mutations in the metabolic enzymes isocitrate dehydrogenase-1 (IDH1) and IDH2 that
produce the oncometabolite D-2-hydroxyglutarate (2-HG) occur frequently in human acute …
produce the oncometabolite D-2-hydroxyglutarate (2-HG) occur frequently in human acute …
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition
A Kernytsky, F Wang, E Hansen… - Blood, The Journal …, 2015 - ashpublications.org
Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG),
have been identified in several tumors, including acute myeloid leukemia. Recent studies …
have been identified in several tumors, including acute myeloid leukemia. Recent studies …