A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases

S Pandey, SK Srivastava… - Expert Opinion on …, 2012 - Taylor & Francis
Introduction: Aldose reductase (AR) was initially thought to be involved in the secondary
diabetic complications because of its glucose-reducing potential. However, evidence from …

Aldose reductase: a novel therapeutic target for inflammatory pathologies

KV Ramana, SK Srivastava - The international journal of biochemistry & …, 2010 - Elsevier
Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose
metabolism, besides reducing glucose to sorbitol, reduces a number of lipid peroxidation …

Development of aldose reductase inhibitors for the treatment of inflammatory disorders

M Chatzopoulou, K Pegklidou… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Accumulating evidence attributes a significant role to aldose reductase (ALR2)
in the pathogenesis of several inflammatory pathologies. Aldose reductase inhibitors (ARIs) …

Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases

A Singh Grewal, S Bhardwaj, D Pandita… - Mini reviews in …, 2016 - ingentaconnect.com
Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

Novel aldose reductase inhibitors: a patent survey (2006–present)

M Chatzopoulou, P Alexiou… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Initially studied for its central role in the pathogenesis of chronic diabetic
complications, aldose reductase (ALR2) gains more attention over the years as its …

Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages

KV Ramana, ABM Reddy, R Tammali… - Free Radical Biology and …, 2007 - Elsevier
Aldose reductase (AR) is a ubiquitously expressed protein with pleiotrophic roles as an
efficient catalyst for the reduction of toxic lipid aldehydes and mediator of hyperglycemia …

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

SK Srivastava, UCS Yadav, ABM Reddy… - Chemico-biological …, 2011 - Elsevier
Oxidative stress-induced inflammation is a major contributor to several disease conditions
including sepsis, carcinogenesis and metastasis, diabetic complications, allergic asthma …

Aldose reductase: a multi-disease target

JN Sangshetti, RS Chouthe, NS Sakle… - Current Enzyme …, 2014 - ingentaconnect.com
Aldose reductase (AR) is an enzyme that catalyzes the rate limiting step of the polyol
pathway of glucose metabolism. Besides reducing glucose to sorbitol, it reduces a number …

Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages

M Shoeb, UCS Yadav, SK Srivastava… - Free Radical Biology and …, 2011 - Elsevier
The bacterial endotoxin lipopolysaccharide (LPS) is known to induce release of arachidonic
acid (AA) and its metabolic products, which play important roles in the inflammatory process …

Aldose reductase: new insights for an old enzyme

KV Ramana - 2011 - degruyter.com
In the past years aldose reductase (AKR1B1; AR) is thought to be involved in the
pathogenesis of secondary diabetic complications such as retinopathy, neuropathy …