Plasma membrane poration induced by ultrasound exposure: implication for drug delivery

S Mehier-Humbert, T Bettinger, F Yan… - Journal of controlled …, 2005 - Elsevier
Sonoporation, in the presence of ultrasound contrast agents (UCA), is a technique that
permits the transfer of drugs, including genes, into cells. In this study, the size of the pores …

Ultrasound-induced cell membrane porosity

CX Deng, F Sieling, H Pan, J Cui - Ultrasound in medicine & biology, 2004 - Elsevier
Recent studies of ultrasound (US) methods for targeted drug delivery and nonviral gene
transfection revealed new, advantageous possibilities. These studies utilized US contrast …

Ultrasound-mediated gene delivery: kinetics of plasmid internalization and gene expression

S Mehier-Humbert, T Bettinger, F Yan… - Journal of Controlled …, 2005 - Elsevier
Sonoporation is an approach that can be used to transfer DNA or drugs into cells. However,
very little is known about the mechanism of ultrasound-mediated membrane …

Ultrasound-directed drug delivery

M Postema, OH Gilja - Current pharmaceutical biotechnology, 2007 - ingentaconnect.com
It has been proven, that the cellular uptake of drugs and genes is increased, when the
region of interest is under ultrasound insonification, and even more when a contrast agent is …

The size of sonoporation pores on the cell membrane

Y Zhou, RE Kumon, J Cui, CX Deng - Ultrasound in medicine & biology, 2009 - Elsevier
Sonoporation uses ultrasound (US) to generate transient nonselective pores on the cell
membrane and has been exploited as a nonviral intracellular drug and gene delivery …

Understanding ultrasound induced sonoporation: definitions and underlying mechanisms

I Lentacker, I De Cock, R Deckers, SC De Smedt… - Advanced drug delivery …, 2014 - Elsevier
In the past two decades, research has underlined the potential of ultrasound and
microbubbles to enhance drug delivery. However, there is less consensus on the …

Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation

M Kinoshita, K Hynynen - Biochemical and biophysical research …, 2007 - Elsevier
Ultrasound-induced intracellular drug delivery, sonoporation, is an appealing and promising
technique for next generation drug delivery system. Many types of molecules, such as …

Effects of extracellular calcium on cell membrane resealing in sonoporation

Y Zhou, J Shi, J Cui, CX Deng - Journal of Controlled Release, 2008 - Elsevier
Sonoporation has been exploited as a promising strategy for intracellular drug and gene
delivery. The technique uses ultrasound to generate pores on the cell membrane to allow …

Intracellular delivery and calcium transients generated in sonoporation facilitated by microbubbles

Z Fan, RE Kumon, J Park, CX Deng - Journal of Controlled Release, 2010 - Elsevier
Ultrasound application in the presence of microbubbles is a promising strategy for
intracellular drug and gene delivery, but it may also trigger other cellular responses. This …

Microbubble mediated sonoporation of cells in suspension: clonogenic viability and influence of molecular size on uptake

R Karshafian, S Samac, PD Bevan, PN Burns - Ultrasonics, 2010 - Elsevier
This work investigates whether the application of sonoporation is limited by the size of a
macromolecule being delivered and by the ability of cells to proliferate following uptake …