The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states that share
the underpinnings of persistent immune cell activation and uninhibited cytokine production …

Cytokines in cytokine storm syndrome

EM Behrens - Cytokine Storm Syndrome, 2019 - Springer
As the eponymous mediators of the cytokine storm syndrome, cytokines are a pleomorphic
and diverse set of soluble molecules that activate or suppress immune functions in a wide …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Since the first textbook devoted to cytokine storm syndromes (CSSs) was published in 2019,
the world has changed dramatically and the term's visibility has broadened. Herein, we …

Weathering the storm: Improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis

LK Weaver, EM Behrens - Current treatment options in rheumatology, 2017 - Springer
Opinion statement Cytokine storm syndromes require rapid diagnosis and treatment to limit
the morbidity and mortality caused by the hyperinflammatory state that characterizes these …

Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome

S Mahajan, CE Decker, Z Yang, D Veis, ED Mellins… - Journal of …, 2019 - Elsevier
Cytokine storm syndrome (CSS) is a life-threatening condition characterized by excessive
activation of T cells and uncontrolled inflammation, mostly described in patients with familial …

Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation

LK Meyer, KC Verbist, S Albeituni… - Blood, The Journal …, 2020 - ashpublications.org
Cytokine storm syndromes (CSS) are severe hyperinflammatory conditions characterized by
excessive immune system activation leading to organ damage and death. Hemophagocytic …

Looking into the IL-1 of the storm: are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes?

TA Gleeson, E Nordling, C Kaiser… - Discovery …, 2022 - academic.oup.com
Inflammasomes and the interleukin (IL)-1 family of cytokines are key mediators of both
inflammation and immunothrombosis. Inflammasomes are responsible for the release of the …

IL-6 blockade in cytokine storm syndromes

D Barrett - Cytokine storm syndrome, 2019 - Springer
Interleukin-6 is well known pro-inflammatory cytokine that is elevated in cytokine storm
syndromes, such as hemophagocytic lymphohistiocytosis (HLH) and macrophage activation …