Bacteria have now been harnessed to combat human diseases, especially to meet the
challenge of antimicrobial resistance. Modulating the microbiome, particularly by genetically …

Naturally occurring microorganisms have been used therapeutically for over a century, but
the advent of modern techniques for genetic manipulation has created unprecedented …

Highlights•Engineered bacteria provide a continuous supply of therapeutic
molecules.•Bacterial therapies target inflammation, immunity, cancer, and metabolic …

The discovery of antimicrobial drugs and their subsequent use has offered an effective
treatment option for bacterial infections, reducing morbidity and mortality over the past 60 …

Bacteria sense and respond to the environment, communicate, and continuously interact
with their surroundings, including host bodies. For more than a century, engineers have …

Antibiotic resistant bacterial infections are a global public health challenge that has been
increasing in severity and scope for the last few decades. Without creative solutions to this …

There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

It was already clinically apparent 150 years ago that bacterial therapy could alleviate
diseases. Recently, a burgeoning number of researchers have been using bacterial …

Lack of pathogen specificity in antimicrobial therapy causes non-discriminant microbial cell
killing that disrupts the microflora present. As a result, potentially helpful microbial cells are …

Microbial products are essential for developing various therapeutic agents, including
antibiotics, anticancer drugs, vaccines, and therapeutic enzymes. Genetic engineering …