Extinction of classically conditioned fear, like its acquisition, is active learning, but little is
known about its molecular mechanisms. We recently reported that temporal massing of …

Variability in fear conditionability is common, and clarity regarding the neural regions
responsible for individual differences in fear conditionability could uncover brain-based …

Anxiety disorders have a high prevalence, and despite the substantial advances in the
psychological treatment of anxiety, relapse is still a common problem. One approach to …

The ability to recognize and properly respond to instances of protection from impending
danger is critical for preventing chronic stress and anxiety—central symptoms of anxiety and …

Post-traumatic stress disorder (PTSD) is a heterogeneous disorder that affects individuals
exposed to trauma (eg, combat, interpersonal violence, and natural disasters). It is …

Rats re-exposed to an environment previously associated with the onset of shocks evoke a
set of conditioned defensive responses in preparation to an eventual flight or fight reaction …

OBJECTIVES: We have recently reported that spontaneously hypertensive rats (SHR)
present a contextual fear conditioning (CFC) deficit. This deficit is improved by antipsychotic …

Background Fear conditioning is implicated as a central psychopathological mechanism of
anxiety disorders. People with anxiety disorders typically demonstrate reduced affective …

The aim of the current study was twofold:(1) to systematically examine differences in fear
conditioning between anxiety patients and healthy controls using meta‐analytic methods …

Exposure therapy builds on the mechanism of fear extinction leading to decreased fear
responses. How the stress hormone cortisol affects brain regions involved in fear extinction …