Non-additive genetic variance for complex traits is traditionally estimated from data on
relatives. It is notoriously difficult to estimate without bias in non-laboratory species …

For human complex traits, non-additive genetic variation has been invoked to explain"
missing heritability," but its discovery is often neglected in genome-wide association studies …

Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …

Understanding genetic variation of complex traits in human populations has moved from the
quantification of the resemblance between close relatives to the dissection of genetic …

To the Editor: Recently, Lee et al. 1 presented a method to estimate the proportion of
phenotypic variation explained by common SNPs for case-control phenotypes. This extends …

Variance-component methods that estimate the aggregate contribution of large sets of
variants to the heritability of complex traits have yielded important insights into the genetic …

We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide
polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero …

Complex traits and common diseases are extremely polygenic, their heritability spread
across thousands of loci. One possible explanation is that thousands of genes and loci have …

Abstract Narrow-sense heritability (h 2) is an important genetic parameter that quantifies the
proportion of phenotypic variance in a trait attributable to the additive genetic variation …

We have recently developed analysis methods (GREML) to estimate the genetic variance of
a complex trait/disease and the genetic correlation between two complex traits/diseases …