With about 400,000 annual deaths worldwide, malaria remains a public health burden in
tropical and subtropical areas, especially in low-income countries. Selection of drug …

Quantitative structure–activity relationship (QSAR) models have been developed for a data
set of 3133 compounds defined as either active or inactive against P. falciparum. Because …

Compared to the previous year, there has been an increase of nearly 2 million malaria
cases in 2021. The emergence of drug-resistant strains of Plasmodium falciparum, the most …

There are very few studies for combinatorial library design and high throughput screening of
4-anilinoquinoline antimalarial compounds having activities against parasitic strain of P …

Background A large number of natural products have shown in vitro antiplasmodial
activities. Early identification and prioritization of these natural products with potential for …

Malaria, the most virulent parasitic disease, has become a devastating health problem in
tropical and subtropical regions, especially in Africa, due to favorable temperature and …

Introduction Due to emerging resistance to the first-line artemisinin-based antimalarials and
lack of efficient vaccines and limited chemotherapeutic alternatives, there is an urgent need …

Malaria is an infectious disease that affects over 216 million people worldwide, killing over
445,000 patients annually. Due to the constant emergence of parasitic resistance to the …

Abstract Development of resistance in the Plasmodium falciparum to Artemisinin, the most
effective anti-malarial compound, threatens malaria elimination tactics. To gain more …

To screen the active antimalarial novel artemisinin derivatives, a QSAR modeling approach
was used. QSAR model showed high correlation (r2= 0.83 and rCV2= 0.81) and indicated …