Immune response resetting as a novel strategy to overcome SARS-CoV-2–induced Cytokine Storm

AE Nowill, PO de Campos-Lima - The Journal of Immunology, 2020 - journals.aai.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), which rapidly became a pandemic of global proportions. Sepsis …

[HTML][HTML] Immunomodulation for severe COVID-19 pneumonia: the state of the art

Y Zhang, Y Chen, Z Meng - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 has become a worldwide pandemic caused by the novel coronavirus named
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severe cases of COVID-19 …

[HTML][HTML] The unleashing of the immune system in COVID-19 and sepsis: the calm before the storm?

S Bellinvia, CJ Edwards, M Schisano, P Banfi… - Inflammation …, 2020 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is sorely testing health care systems and …

[HTML][HTML] COVID-19: imbalanced immune responses and potential immunotherapies

B Xie, J Zhang, Y Li, S Yuan, Y Shang - Frontiers in Immunology, 2021 - frontiersin.org
The ongoing pandemic coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading and has resulted in …

Immune immunomodulation in coronavirus disease 2019 (COVID-19): strategic considerations for personalized therapeutic intervention

MW Hall, I Joshi, L Leal, EE Ooi - Clinical Infectious Diseases, 2022 - academic.oup.com
We are learning that the host response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection is complex and highly dynamic. Effective initial host defense in the …

Prevention and treatment of COVID‐19 disease by controlled modulation of innate immunity

V Schijns, EC Lavelle - European journal of immunology, 2020 - Wiley Online Library
The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global …

[HTML][HTML] Weathering the storm: harnessing the resolution of inflammation to limit COVID-19 pathogenesis

E Silberberg, JG Filep, A Ariel - Frontiers in Immunology, 2022 - frontiersin.org
The resolution of inflammation is a temporally and spatially coordinated process that in its
innate manifestations, primarily involves neutrophils and macrophages. The shutdown of …

[HTML][HTML] Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19

X Wang, Z He, X Zhao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
A cytokine storm is an uncontrolled, excessive immune response that contributes to the
pathogenesis of coronavirus disease 2019 (COVID‑19). Viral infections lead to the loss of …

[HTML][HTML] Could coronavirus disease 2019 (COVID-19) render natural immunity to re-infections? a spotlight on the therapeutic pipeline

MA Abid, L Nunley, MB Abid - Frontiers in Immunology, 2020 - frontiersin.org
The pandemic of Corona Virus Disease 2019 (COVID-19) caused by a novel coronavirus,
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is continuing to cause …

[HTML][HTML] Trained immunity: an overview and the impact on COVID-19

JM Brueggeman, J Zhao, M Schank, ZQ Yao… - Frontiers in …, 2022 - frontiersin.org
Effectively treating infectious diseases often requires a multi-step approach to target different
components involved in disease pathogenesis. Similarly, the COVID-19 pandemic has …