Duloxetine (DLX) is a selective serotonin and noradrenaline reuptake inhibitor (SNRI) used
for the treatment of pain, but it has been reported to show side effects in 10–20% of patients …

Tricyclic antidepressants (TCAs) have potent local pain blockade properties that could be of
interest in relieving chronic pain states as neuropathic pain. The aim of this work was to …

Neuroinflammation is a condition that contributes significantly to the pathogenesis and
progression of several neurodegenerative disorders. Targeting neuroinflammation is a novel …

Aim: Amitriptyline (AMI) has been used to treat neuropathic pain. However, the clinical
outcomes remain unsatisfactory, presumably due to a limited understanding of the …

Lamotrigine (LTG), a sodium and calcium channel blocker, has demonstrated efficacy for the
treatment of neuropathic pain in multiple, randomized, controlled trials. However, its …

Targeting microglial activation is emerging as a clinically promising drug target for
neuropathic pain treatment. Fexofenadine, a histamine receptor 1 antagonist, is a clinical …

Introduction Esketamine, one of the few non-opioid potent analgesics, has demonstrated
efficacy in the treatment of various chronic pain, particularly neuropathic pain. However, its …

Given the poor bioavailability of curcumin, its antinociceptive effects are produced after
chronic intravenous administration of high doses, while poly (d, l-lactide-co-glycolide) …

Microglia play a critical role in neuropathic pain. Since upregulated Foxp3 in microglia
enhances tissue repair by resolving neuroinflammation in excitotoxin-induced neuronal …

Abstract Aim Baclofen and Lamotrigine via PLGA nanoparticles were developed for nose-to-
brain delivery for the treatment of Neuropathic pain. Methods Nanoparticles were prepared …