Inflammatory cell infiltration, cytokine release, epithelial damage, airway/lung remodelling
and fibrosis are central features of inflammatory lung disorders, which include asthma …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Airway and pulmonary fibrosis is a pathological condition associated with chronic airway
inflammation. Fibrosis and architectural remodeling of tissues can severely disrupt lung …

Chronic respiratory disorders affect millions of people worldwide. Pathophysiological
changes to the normal airway wall structure, including changes in the composition and …

Although asthma is classically defined as reversible airflow obstruction and often remits in
younger subjects with milder disease, a proportion of asthmatics experience chronic …

Current therapies to mitigate inflammatory responses involved in airway remodeling and
associated pathological features of asthma and chronic obstructive pulmonary disease …

Asthma is a chronic disease of the airways that has long been viewed predominately as an
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …

Airway inflammation, airway remodeling and airway hyperresponsiveness are the
fundamental components of pathogenesis that lead to symptoms and lung function changes …

Pulmonary fibrosis is characterized by lung inflammation and abnormal tissue repair,
resulting in the replacement of normal functional tissue with an abnormal accumulation of …

Airway inflammation, airflow obstruction, and bronchial hyperresponsiveness are
characteristic phenotypic features of asthma. Clinically, airflow obstruction in asthma often is …