Immunobiology of human cytomegalovirus: from bench to bedside

T Crough, R Khanna - Clinical microbiology reviews, 2009 - Am Soc Microbiol
Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Human cytomegalovirus cell tropism and pathogenesis

C Sinzger, G Jahn - Intervirology, 1996 - karger.com
The human cytomegalovirus (HCMV) can cause lifelong infection with episodes of
endogenous reactivation. Intrauterine fetal infection and infection of immunocompromised …

Ex Vivo Profiling of CD8+-T-Cell Responses to Human Cytomegalovirus Reveals Broad and Multispecific Reactivities in Healthy Virus Carriers

R Elkington, S Walker, T Crough, M Menzies… - Journal of …, 2003 - Am Soc Microbiol
Human cytomegalovirus (HCMV) can establish both nonproductive (latent) and productive
(lytic) infections. Many of the proteins expressed during these phases of infection could be …

The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?

MR Wills, E Poole, B Lau, B Krishna… - Cellular & molecular …, 2015 - nature.com
While the host immune response following primary human cytomegalovirus (HCMV)
infection is generally effective at stopping virus replication and dissemination, virus is never …

Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease

W Britt - Human cytomegalovirus, 2008 - Springer
Infections with human cytomegalovirus (HCMV) are a major cause of morbidity and mortality
in humans with acquired or developmental deficits in innate and adaptive immunity. In the …

Human cytomegalovirus latency and reactivation–a delicate balance between the virus and its host's immune system

C Söderberg-Nauclér, JA Nelson - Intervirology, 2000 - karger.com
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that still causes severe
morbidity and mortality in immunocompromised individuals. During its evolution, the virus …

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8+ T Lymphocytes in Healthy Seropositive Donors

GMA Gillespie, MR Wills, V Appay… - Journal of …, 2000 - Am Soc Microbiol
Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent
host, but remains a major cause of morbidity in immunosuppressed individuals. Using the …

The pathogenesis of human cytomegalovirus

P Griffiths, I Baraniak, M Reeves - The Journal of pathology, 2015 - Wiley Online Library
Human cytomegalovirus (HCMV) is a recognized cause of disease in the fetus, the allograft
recipient and AIDS patients. More recently, it has been recognized as a pathogen for those …

Controlling cytomegalovirus: helping the immune system take the lead

PJ Hanley, CM Bollard - Viruses, 2014 - mdpi.com
Cytomegalovirus, of the Herpesviridae family, has evolved alongside humans for thousands
of years with an intricate balance of latency, immune evasion, and transmission. While …