Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila
Histone post-translational modifications (PTMs) and differential incorporation of variant and
canonical histones into chromatin are central modes of epigenetic regulation. Despite …
canonical histones into chromatin are central modes of epigenetic regulation. Despite …
Direct interrogation of the role of H3K9 in metazoan heterochromatin function
A defining feature of heterochromatin is methylation of Lys9 of histone H3 (H3K9me), a
binding site for heterochromatin protein 1 (HP1). Although H3K9 methyltransferases and …
binding site for heterochromatin protein 1 (HP1). Although H3K9 methyltransferases and …
Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila
HK Graves, P Wang, M Lagarde, Z Chen… - Epigenetics & …, 2016 - Springer
Background Understanding the function of histone post-translational modifications is the key
to deciphering how genomic activities are regulated. Among the least well-understood …
to deciphering how genomic activities are regulated. Among the least well-understood …
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
J Bernués, A Izquierdo-Boulstridge… - Nucleic Acids …, 2022 - academic.oup.com
Post-translational modifications (PTMs) of core histones are important epigenetic
determinants that correlate with functional chromatin states. However, despite multiple linker …
determinants that correlate with functional chromatin states. However, despite multiple linker …
Transcription in the absence of histone H3. 2 and H3K4 methylation
M Hödl, K Basler - Current Biology, 2012 - cell.com
Histone H3 proteins play fundamental roles in DNA packaging, gene transcription, and the
transmission of epigenetic states. In addition to posttranslational modifications of their N …
transmission of epigenetic states. In addition to posttranslational modifications of their N …
Transcription in the absence of histone H3. 3
M Hödl, K Basler - Current Biology, 2009 - cell.com
Di-and trimethylation of histone H3 lysine 4 (H3K4me2 and H3K4me3) are hallmarks of
chromatin at active genes [1]. The major fraction of K4-methylated histone H3 is the variant …
chromatin at active genes [1]. The major fraction of K4-methylated histone H3 is the variant …
A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation
Organismal development and cell differentiation critically depend on chromatin state
transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and …
transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and …
Molecular Landscape of Modified Histones in Drosophila Heterochromatic Genes and Euchromatin-Heterochromatin Transition Zones
JC Yasuhara, BT Wakimoto - PLoS genetics, 2008 - journals.plos.org
Constitutive heterochromatin is enriched in repetitive sequences and histone H3-methylated-
at-lysine 9. Both components contribute to heterochromatin's ability to silence euchromatic …
at-lysine 9. Both components contribute to heterochromatin's ability to silence euchromatic …
Evolution of H3K27me3-marked chromatin is linked to gene expression evolution and to patterns of gene duplication and diversification
Histone modifications are critical for the regulation of gene expression, cell type
specification, and differentiation. However, evolutionary patterns of key modifications that …
specification, and differentiation. However, evolutionary patterns of key modifications that …
Genome-scale profiling of histone H3. 3 replacement patterns
Y Mito, JG Henikoff, S Henikoff - Nature genetics, 2005 - nature.com
Histones of multicellular organisms are assembled into chromatin primarily during DNA
replication. When chromatin assembly occurs at other times, the histone H3. 3 variant …
replication. When chromatin assembly occurs at other times, the histone H3. 3 variant …