Glioblastoma (GB) is the most aggressive primary brain cancer of adulthood, associated with
an average 5-year survival rate of 2%(1). A small population of tumor-initiating cells, termed …

Our understanding of the complexity of nervous system cancers has been enhanced through
the incorporation of cellular heterogeneity into tumor models, with cellular subsets …

Cancer arises due to genetic alterations, which allow cells to proliferate uncontrollably and
acquire other features to become an invasive tumor. The rationale behind the traditional …

Over the past 2 decades, the cancer stem cell (CSC) hypothesis has provided insight into
many malignant tumors, including glioblastoma (GBM). Cancer stem cells have been …

Glioblastoma is a primary tumor of the brain with a poor prognosis. Pathological examination
shows that this disease is characterized by intra-tumor morphological heterogeneity, while …

Glioblastoma (GBM) is an incurable disease with high intratumoral heterogeneity.
Bioinformatic studies have examined transcriptional heterogeneity with differing …

There has been increasing awareness that glioblastoma, which may seem
histopathologically similar across many tumors, actually represents a group of molecularly …

Cancer stem cells (CSCs) or cancer initiating cells (CICs) maintain self-renewal and
multilineage differentiation properties of various tumors, as well as the cellular heterogeneity …

Although tumor-propagating cells can be derived from glioblastomas (GBM) of the proneural
and mesenchymal subtypes, a glioma stem-like cell (GSC) of the classic subtype has not …

Cellular heterogeneity is one of the key contributors to poor clinical outcome in glioblastoma
(GBM). In this issue Lathia and colleagues 1 report on the development of a novel mouse …