We evaluated three groups of elderly individuals who were carefully screened to rule out
clinically significant diseases that could affect cognition. They were matched for age and …

OBJECTIVE: Neuropathological evidence suggests that the earliest changes in Alzheimer's
disease selectively affect the parahippocampal regions of the brain. This study was …

Hippocampal atrophy is a marker of Alzheimer disease (AD). It remains unclear whether this
holds true for younger patients as well. Hippocampal volume was measured on MRI scans …

The volume of the hippocampus measured with structural magnetic resonance imaging
(MRI) is increasingly used as a biomarker for Alzheimer's disease (AD). However, the …

We investigated the hippocampal region in six patients diagnosed with possible Alzheimer's
disease (AD), eight patients with probable AD, and eight agematched controls, using a high …

Atrophy of the hippocampal formation, a region important for the acquisition of new
declarative knowledge, has been well‐documented in Alzheimer's disease (AD), although …

The hippocampal formation (HF) is known from pathological and MRI studies to be severely
atrophied in established Alzheimer's disease. However, it is unclear when the earliest …

Context Imaging measurements may aid in the characterization and diagnosis of patients
with Alzheimer disease (AD). Most research studies, however, have been performed on …

PURPOSE To test the hypothesis that atrophy of the hippocampal formation in nondemented
elderly individuals would predict subsequent Alzheimer disease. METHOD We studied 86 …

Delayed memory impairments and medial temporal-lobe atrophy are considered to be
cardinal features of Alzheimer's disease (AD). The goal of the present magnetic resonance …