[HTML][HTML] Role of the NLRP3 inflammasome in neurodegenerative diseases and therapeutic implications

Y Duan, N Kelley, Y He - Neural regeneration research, 2020 - journals.lww.com
Neurodegenerative diseases are a group of neuronal disorders caused by progressive
neuronal cell death in different regions of the human brain. Alzheimer's disease (AD) and …

[HTML][HTML] Key mechanisms and potential targets of the NLRP3 inflammasome in neurodegenerative diseases

Y Guan, F Han - Frontiers in Integrative Neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …

[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

[HTML][HTML] Targeting NLRP3 inflammasome in the treatment of CNS diseases

BZ Shao, Q Cao, C Liu - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Central nervous system (CNS) is one of the largest killers of people's health all over the
world. The overactivation of the immune and inflammatory responses is considered as an …

[HTML][HTML] Targeting NLRP3 inflammasome in translational treatment of nervous system diseases: an update

Q Yu, T Zhao, M Liu, D Cao, J Li, Y Li, M Xia… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammatory response is the immune response mechanism of the innate immune
system of the central nervous system. Both primary and secondary injury can activate …

[HTML][HTML] NLRP3 Inflammasome's Activation in Acute and Chronic Brain Diseases—An Update on Pathogenetic Mechanisms and Therapeutic Perspectives with …

A Chiarini, L Gui, C Viviani, U Armato, I Dal Prà - Biomedicines, 2023 - mdpi.com
Increasingly prevalent acute and chronic human brain diseases are scourges for the elderly.
Besides the lack of therapies, these ailments share a neuroinflammation that is …

The NLRP3 inflammasome as a bridge between neuro-inflammation in metabolic and neurodegenerative diseases

G Söderbom, BY Zeng - International Review of Neurobiology, 2020 - Elsevier
Evidence increasingly suggests that type 2 diabetes mellitus (T2DM) is a risk factor for
neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD) and Parkinson's …

[HTML][HTML] The role of NLRP3 inflammasome in Alzheimer's disease and potential therapeutic targets

T Liang, Y Zhang, S Wu, Q Chen, L Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive dysfunction and behavioral impairment. The typical …

[HTML][HTML] Neurodegenerative disease and the NLRP3 inflammasome

JA Holbrook, HH Jarosz-Griffiths, E Caseley… - Frontiers in …, 2021 - frontiersin.org
The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …

NLRP3 inflammasome in neurodegenerative disease

FL Anderson, KE Biggs, BE Rankin, MC Havrda - Translational Research, 2023 - Elsevier
Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …